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PD-1, IHC with Interpretation

Test Code
91321


CPT Codes
88342

Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block


Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides


Instructions
Please include surgical pathology report.


Transport Container
IHC Specimen Transport Kit


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen


Methodology
Immunohistochemistry (IHC)

Setup Schedule
Set up: Mon-Fri a.m.; Report available: 3 days


Reference Range
See Laboratory Report


Clinical Significance
The programmed death-1 (PD1) protein is expressed by follicular helper T-cells and is useful in the diagnosis of T-cell lymphomas and in highlighting L&H cells in Hodgkin lymphoma. Anti-PD-1 antibody has been used as anti-tumor immunotherapy agents. This effect is possibly due to the targeting of PD1 expressing tumor-infiltrating lymphocytes which can be enumerated by this antibody.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.