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TIA-1, IHC with Interpretation
Test Code90186
CPT Codes
88342
Preferred Specimen
Minimum: 1 formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
3 unstained slides, positively charged, submitted in an IHC specimen transport kit
Instructions
Please include surgical pathology report.
Transport Container
IHC specimen transport kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri; a.m.; Report available: 3 days
Reference Range
See Laboratory Report
Clinical Significance
TIA-1, a cytoplasmic/granule marker that is associated with cytotoxic lymphocytes, is positive in T-cell and NK large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas and pulmonary angiocentric lymphomas of T or NK phenotype. Most anaplastic large cell lymphomas will also show variable reactivity.
