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ACTH, Plasma, 2 specimens [30986X]
Test Code30986
CPT Codes
82024 (x2)
Preferred Specimen
1.5 mL plasma collected in (x2) EDTA (lavender-top) tubes
Minimum Volume
0.5 mL (x2)
Other Acceptable Specimens
0.5 mL plasma collected in (x2) PPT potassium EDTA (white-top) tube
Instructions
2 specimens: 1.5 mL plasma collected in an EDTA (lavender-top tube) per specimen; note time on tubes. Collect specimens between 7 a.m. and 10 a.m. If drawn at any other time, the reference ranges do not apply. Centrifuge immediately after collection to separate plasma from cells. Transfer plasma to separate, plastic, specimen transport containers or vials and mark the specimen type as plasma on both containers. Freeze immediately and ship both specimens frozen in the same shipping container.
ACTH measurement is not recommended for patients who have been administered cosyntropin (ACTH (1-24)) because the results may be falsely elevated or depressed. Reference: Siemens Healthcare Customer Notification IMC20-04.A.US March 25, 2020.
ACTH measurement is not recommended for patients who have been administered cosyntropin (ACTH (1-24)) because the results may be falsely elevated or depressed. Reference: Siemens Healthcare Customer Notification IMC20-04.A.US March 25, 2020.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 16 hours
Refrigerated: 24 hours
Frozen: 28 days
Refrigerated: 24 hours
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received thawed
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: Next day
Reference Range
| <3 Years | Not established |
| 3-17 Years | 9-57 pg/mL |
| ≥18 Years | 6-50 pg/mL |
Clinical Significance
Determination of ACTH is useful in differentiating between primary and secondary adrenocortical hypo- and hyperfunctional disorders: Addison's disease, Cushing's syndrome, adrenal carcinoma, ectopic ACTH syndrome, and adrenal nodular hyperplasia.
